Chromatin Structure and Dynamics: Recent Advancements
Recent advancements in the study of chromatin structure and dynamics have been nothing short of revolutionary, both in computational methodologies and experimental techniques. On the computational front, integrating machine learning and sophisticated algorithms has propelled our ability to model chromatin organization with unprecedented accuracy, unveiling intricate three-dimensional folding patterns and their functional implications. Experimentally, breakthroughs in high-resolution imaging techniques, such as super-resolution microscopy and Hi-C, have offered unparalleled glimpses into the spatial organization of chromatin at a finer scale. Collectively, these strides are reshaping our understanding of chromatin folding, paving the way for groundbreaking discoveries in genomics and cellular biology.
Topics covered include, but are not limited to:
- Equilibrium chromosome folding mechanisms
- Non-equilibrium chromosome folding mechanisms
- Coupling between nuclear landmarks and genome organization
- Phase separation in genome organization
Guest Editors
Bin Zhang, Massachusetts Institute of Technology
Tamar Schlick, New York University
More information:
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