Biochemistry, molecular biology, and structural biology uncover increasingly detailed parts of living systems. Bioinformatics allows scientists to annotate and integrate these data, giving rise to systems biology, which seeks to reconstruct networks of molecular interactions behind emergent biophysical functions of different cell types. Biological systems depend critically on their dynamic three-dimensional organization to achieve robust physiological functions. Building tools and analyses that integrate structurally across physical scales—from molecule all the way to organism—is a defining problem of modern biophysics. The need for multiscale modeling and analysis is apparent in medicine. Patients’ symptoms manifest at the tissue, organ, and body scales. Still, medical therapies target specific molecules or operate on single organs without integrating critical cell-cell, cell-tissue, and cell-organ couplings. This Special Topic seeks to better understand these multiscale relationships in order to better inform medical science.
Topics covered include, but are not limited to:
- Multiscale multiphysics modeling of tissue and organ systems
- Multiscale imaging
- Multiscale modeling of cell and molecular biophysics
- Multiscale systems biology
- Multiscale theoretical and computational analysis
Alessio Gizzi, University Campus Bio-Medico of Rome
Andrew McCulloch, University of California – San Diego
Corina Drapaca, Pennsylvania State University
Christian Brosseau, Deputy Editor
Marcela Bilek, Associate Editor
Submission and acceptance criteria:
Manuscripts considered for publication in Journal of Applied Physics are expected to meet the journal’s standard of acceptance: to report on original and timely results that significantly advance understanding in contemporary applied physics. Material that is exclusively review in nature is not considered for publication. Manuscripts submitted for consideration in this Special Topic must meet the same criteria and will undergo the journal’s standard peer-review process. The Editorial Team of Journal of Applied Physics will issue final decisions on the submitted manuscripts. Manuscripts will publish immediately upon acceptance.
For more information on the journal’s editorial policies, please click here.
Manuscripts must be submitted through the online submission system (PXP) of Journal of Applied Physics. Please select the Special Topic “Multiscale Modeling & Analysis in Biophysics” to submit your manuscript for consideration in this Special Topic.