Microfluidics Circulating Biomarkers and Cancer
Recent advances in cancer research suggest that rich diagnostic and prognostic information can be present in blood-based biomarkers including circulating tumor DNA (ctDNA), circulating tumor cells (CTCs), and exosomes. Nevertheless, technological challenges remain in isolating these circulating biomarkers and performing downstream molecular assays for routine screenings and longitudinal studies. The field of microfluidics has advanced significantly and is poised to address these challenges, making a significant impact on the development of liquid biopsy technologies for cancer diagnostics and management. In this special issue, we invite articles from the community on microfluidic approaches for isolation and detection of cancer relevant circulating biomarkers.
Topics covered include, but are not limited to:
- Physicochemical principles for isolation and enrichment of CTCs, ctDNA and exosomes
- Techniques for molecular profiling of circulating biomarkers
- Label-free approaches for detection of cancer biomarkers
- Single-cell level assays (sequencing, ELISA, proteomics)
- Focused technical reviews on separation and analysis of circulating biomarkers
- Perspectives on clinical challenges to translate discoveries in circulating biomarkers to cancer prevention and treatment
Guest Editors
Siva A. Vanapalli – Texas Tech University
Soojung Claire Hur – Johns Hopkins University
How to Submit:
- Authors should log into PXP to submit a manuscript
- For “Manuscript Type” select “41 – Regular Articles”
- Under the “Special Topic” drop-down menu, select “Microfluidics, Circulating Biomarkers and Cancer”