MELVILLE, NY, Oct. 30, 2023 — Congratulations to this year’s Biomicrofluidics Best Paper Award winners! Announced each year at the MicroTAS Conference and sponsored by AIP Publishing, the Biomicrofluidics Best Paper Award recognizes exceptional accomplishments by PhD students and young researchers in papers submitted to the conference.
All submitted papers are graded by the MicroTAS Technical Program Committee and Executive Technical Program Committee. Those committees then select approximately 25 papers, each submitted by students or young researchers at the post-doctoral level, as finalists. The finalists are evaluated by a small committee consisting of Executive Technical Program committee members and members of the Chemical and Biological Microsystems Society board.
This year’s winners are:
A Vascularized Multi-Composition Tumor Array Bioprinted on a Microfluidic Cell Culture and Drug Screening System for Multivariable Analysis
Gihyun Lee, Soo Jee Kim, and Je-Kyun Park, Korea Advanced Institute of Science and Technology (KAIST), Korea
This paper describes an integration technique of bioprinting and a high-functional microfluidic platform for multivariable screening in a multi-composition tumor microenvironment (TME) array bioprinted on a microfluidic substrate. Thirty-six TME models were printed on a single device, and the vascular barrier surrounding cancer spheroids was observed in the model. The multivariable analysis was demonstrated by treating four drug concentrations on the TME array consisting of three compositional groups.
Multi-step Droplet Microfluidic Platform for High-Content Single-Cell Sequencing
Tomasz S. Kaminski, Joachim De Jonghe, and Florian Hollfelder, University of Warsaw, Poland, University of Cambridge, UK, and Francis Crick Institute, UK
Droplet microfluidic methods have massively increased the throughput of single-cell sequencing. The benefit of scale-up is, however, accompanied by increased background noise, and the overall RNA capture efficiency is lower. To tackle these bottlenecks, the authors introduced a spinDrop — a novel method that performs on-chip sorting to enrich for droplets that contain single cells and next use picoinjection to perform multi-step lysis and reverse transcription for sensitive 3’ mRNA profiling.
Spatiotemporally Generated Microvortexes Weave Laminar Flow
Makoto Saito, Niko Kimura, Yoko Yamanishi, and Shinya Sakuma, Kyushu University, Japan
The authors introduced an unprecedent microfluidic folding method utilizing spatiotemporally generated microvortexes by the physical interaction between microchannels and pulsed jet flow. The method enables users to inject jet liquid into main flow just like warp and weft in weaving, which contribute to controlling the interaction space of molecules in self-assembly. The team applied the method to produce lipid-based nanoparticles and succeeded in controlling their size by varying the frequency of vortex generation.
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Biomicrofluidics publishes research highlighting fundamental physiochemical mechanisms associated with microfluidic and nanofluidic phenomena as well as novel microfluidic and nanofluidic techniques for diagnostic, medical, biological, pharmaceutical, environmental, and chemical applications.
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